Personal Data

Marat MUKHTAROVName: Marat MUKHTAROV
Business Address:
420008, Kazan Federal (Volga Region) University, room 024B, Kremlyovskaya St., 18, Kazan, Russia
Phone: +7 (843) 233 78 24
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Date of Birth: 14.11.1974

 

Education and Academic Degrees

  • 1996 – graduated from Kazan State University, Department of Physics, speciality – “Radiophysics and electronics”, Kazan, Russia
  • 1996-1999 – postgraduate student at Kazan Institute of Biochemistry and Biophysics of Russian Academy of Sciences, speciality – “Biophysics”, Kazan, Russia
  • 2000 – Ph.D. in Biology (Human and Animals Physiology), “Role of nitric oxide (NO) in the regulation of transmitter release at the rat neuromuscular junction” from Kazan State Pedagogical University, Kazan, Russia

 

Positions held

  • 1999-2004 – Researcher at Kazan Institute of Biochemistry and Biophysics of Russian Academy of Sciences, Laboratory of Biophysics of Synaptic Processes, Kazan, Russia
  • 2002-2012 – PostDoc at INMED INSERM U901, , l’Université d’Aix-Marseille, Marseille, France;
  • from 12/2010 – PostDoc at INS INSERM UMR 1106, Faculté de Médecine La Timone, l’Université d’Aix-Marseille, Marseille, France
  • 2012-... - Research associate, Laboratory of Neurobiology, Institute of Fundamental Medicine and Biology, KFU

 

Teaching activities

1999-2002 – Assistant Professor at Kazan State Medical University, Department of Medical and Biological Physics, Kazan, Russia

 

Areas of Specializations

Synaptic transmission in the neuromuscular junction, non-quantal release of acetylcholine, glycinergic synaptic transmission in hypoglossal motoneurons and retinal cells, role of intracellular calcium in modulation of synaptic transmission, genetically encoded optical chloride sensors, chloride homeostasis in nervous system, network activity in neonatal brain slices

 

Grants/Fellowships

  • 1996-1998 (CoPI), 1999-2001 (CoPI), 2002-2003 (PI) – Grants of Russian Foundation of Basic Researches, Kazan, Russia
  • 1998-1999 (CoPI), 2001-2002 (PI) – Grants of Tatar Academy of Sciences, Kazan, Russia
  • 2001 – IBRO Scholarship Against Brain-Drain, Kazan, Russia
  • 2002 – NATO Scientific Research Fellowship (06.09.2002 – 05.06.2003), INMED INSERM U29, Marseille
  • 2003 – Fondation pour la Recherche Médical (FRM) Fellowship (01.09.2003 – 31.08.2004), INMED INSERM U29, Marseille
  • 2004 – INSERM/IBRO Fellowship (01.10.2004 – 30.09.2005), INMED INSERM U29, Marseille
  • 2006 – Association Française contre les Myopathies (AFM) Fellowship (01.05.2006 – 30.04.2007), INMED INSERM U29, Marseille
  • 2007 – Association Française contre les Myopathies (AFM) Fellowship (01.12.2007 – 30.11.2008), INMED INSERM U901, Marseille
  • 2009 – NEUROCYPRES grant from the European Commission Seventh Framework Programme, INMED INSERM U901, Marseille (01.01.2009 – 31.12.2010)
  • 2012 – ANR Grant, INS INSERM UMR 1106, Marseille, France (01.02.2012 – 31.07.2012)
  • 2012-2014 – Grant of the Government of the Russian Federation to the Leading Scientists №11.G34.31.0075, Institute of Fundamental Medicine and Biology, Kazan Federal University

 

Publications

Intracellular Blockade of GABAa Receptors in the Rat Hippocampal Neurons

I. Khalilov, X. Leinekugel, M. Mukhtarov, R. Khazipov; Biochemistry (Moscow) Supplement Series A:
Membrane and Cell Biology, 2014, Vol. 8, No. 2, pp. 162–168.; 2014
PDF

Transgenic mouse lines for non-invasive ratiometric monitoring of intracellular chloride

Batti L., Mukhtarov M., Audero E., Ivanov A., Paolicelli R., Zurborg S., Gross C., Bregestovski P., Heppenstall P.A.; Front. Cell. Neurosci., 2013, V. 6, № 11, P. 1-14 PDF

Calibration and function alanalysis of three genetically encoded Cl−/pH sensors

Mukhtarov M., Liguori L., Waseem T., Rocca F., Buldakova S., Arosio D., Bregestovski P.;
Front. Mol. Neurosci., 2013, V. 6, № 9, P. 1-16. PDF

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Malkov A., Ivanov A.I., Popova I., Mukhtarov M., Gubkina O., Waseem T., Bregestovski P., Zilberter Y. Reactive oxygen species initiate a metabolic collapse in hippocampal slices: potential trigger of cortical spreading depression. J. Cereb. Blood Flow Metab. 2014; 34(9): 1540-1549.

Ivanov A.I., Malkov A.E., Waseem T., Mukhtarov M., Buldakova S., Gubkina O., Zilberter M., Zilberter Y. Glycolysis and oxidative phosphorylation in neurons and astrocytes during network activity in hippocampal slices. J. Cereb. Blood Flow Metab. 2014; 34(3): 397-407.

Khalilov I., Leinekugel X., Mukhtarov M., Khazipov R. Intracellular blockade of GABAA receptors in the rat hippocampal neurons. Биологические мембраны 2014; 31(1): 25-32. (RU)

Zilberter M., Ivanov A., Ziyatdinova S., Mukhtarov M., Malkov A., Alpár A., Tortoriello G., Botting C.H., Fülöp L., Osypov A.A., Pitkänen A., Tanila H., Harkany T., Zilberter Y. Dietary energy substrates reverse early neuronal hyperactivity in a mouse model of Alzheimer's disease. J. Neurochem. 2013; 125(1):157-171.

Lozovaya N., Mukhtarov M., Tsintsadze T., Ledent C., Burnashev N., Bregestovski P. Frequency-Dependent Cannabinoid Receptor-Independent Modulation of Glycine Receptors by Endocannabinoid 2-AG. Front. Mol. Neurosci. 2011; 4:13.

Ivanov A., Mukhtarov M., Bregestovski P., Zilberter Y. Lactate Effectively Covers Energy Demands during Neuronal Network Activity in Neonatal Hippocampal Slices. Front. Neuroenergetics. 2011; 3:2.

Pellegrino C., Gubkina O., Schaefer M., Becq H., Ludwig A., Mukhtarov M., Chudotvorova I., Corby S., Salyha Y., Salozhin S., Bregestovski P., Medina I. Knocking down of the KCC2 in rat hippocampal neurons increases intracellular chloride concentration and compromises neuronal survival. J. Physiol. 2011; 589(10): 2475-2496.

Mukhtarov M., Ivanov A., Zilberter Y., Bregestovski P. Inhibition of spontaneous network activity in neonatal hippocampal slices by energy substrates is not correlated with intracellular acidification. J. Neurochem. 2011; 116(2): 316-321.

Waseem T., Mukhtarov M., Buldakova S., Medina I., Bregestovski P. Genetically encoded Cl-Sensor as a tool for monitoring of Cl-dependent processes in small neuronal compartments. J. Neurosci. Methods. 2010; 193(1): 14-23.

Holmgren C.D., Mukhtarov M., Malkov A.E., Popova I.Y., Bregestovski P., Zilberter Y. Energy substrate availability as a determinant of neuronal resting potential, GABA signaling and spontaneous network activity in the neonatal cortex in vitro. J. Neurochem. 2010; 112(4): 900-912.

Bregestovski P., Waseem T., Mukhtarov M. Genetically encoded optical sensors for monitoring of intracellular chloride and chloride-selective channel activity. Front. Mol. Neurosci. 2009; 2:15. Review.

Tyzio R., Khalilov I., Represa A., Crepel V., Zilberter Y., Rheims S., Aniksztejn L., Cossart R., Nardou R., Mukhtarov M., Minlebaev M., Epsztein J., Milh M., Becq H., Jorquera I., Bulteau C., Fohlen M., Oliver V., Dulac O., Dorfmüller G., Delalande O., Ben-Ari Y., Khazipov R. Inhibitory actions of the gamma-aminobutyric acid in pediatric Sturge-Weber syndrome. Ann. Neurol. 2009; 66(2): 209-218.

Mukhtarov M., Markova O., Real E., Jacob Y., Buldakova S., Bregestovski P. Monitoring of chloride and activity of glycine receptor channels using genetically encoded fluorescent sensors. Phil. Trans. R. Soc. A. 2008; 366(1880): 3445-3462.

Markova O., Mukhtarov M., Real E., Jacob Y., Bregestovski P. Genetically encoded chloride indicator with improved sensitivity. J. Neurosci. Methods. 2008; 170(1): 67-76.

Malomouzh A.I., Mukhtarov M.R., Nikolsky E.E., Vyskočil F. Muscarinic M1 acetylcholine receptors regulate the non-quantal release of acetylcholine in the rat neuromuscular junction via NO-dependent mechanism. J. Neurochem. 2007; 102(6): 2110-2117.

Bregestovski P., Mukhtarov M. Synaptic function and modulation of glycine receptor channels in the hypoglossal nucleus. Neirofiziol./ Neurophysiol. 2007; 39(4-5): 338-349. Review.

Маломуж А.И., Мухтаров М.Р., Никольский Е.Е. Участие мускариновых холинергических рецепторов в регуляции интенсивности неквантового освобождения ацетилхолина из двигательных нервных окончаний крысы. ДАН. 2007; 414(2): 280-282.

Mukhtarov M., Ragozzino D., Bregestovski P. Dual Ca2+ modulation of glycinergic synaptic currents in rodent hypoglossal motoneurones. J. Physiol. 2005; 569(3): 817-831.

Ragozzino D., Mukhtarov M., Bregestovski P. Depolarization-induced Ca2+ influx modulates glycinergic synaptic currents in rat hypoglossal motoneurons. J. Physiol. 2003; 547P. C103b.

Malomouzh A.I., Mukhtarov M.R., Nikolsky E.E., Vyskočil F., Lieberman E.M., Urazaev A.Kh. Glutamate regulation of non-quantal release of acetylcholine in the rat neuromuscular junction. J. Neurochem. 2003; 85(1): 206-213.

Ахмерова Р.У., Бадрутдинов Л.Р., Белоусова М.В., Галеев А.М., Гиматдинов Р.С., Дружинин Г.А., Мухтаров М.Р., Оранская Т.И., Струнский Е.Г., Шамсутдинова М.К., Шегеда В.Н., под редакцией проф. Никольского Е.Е. Методическое пособие по медицинской и биологической физике. Лабораторный практикум. КГМУ / Казанский государственный медицинский университет. Казань. 2002. 175С.

Galkin A.V., Giniatullin R.A., Mukhtarov M.R., Grishin S.N., Švandová I., Vyskočil F. ATP but not adenosine inhibits nonquantal acetylcholine release at the mouse neuromuscular junction. Eur. J. Neurosci. 2001; 13(11): 2047-2053.

Маломуж А.И., Мухтаров М.Р., Уразаев А.Х., Никольский Е.Е., Выскочил Ф. Влияние глутамата на процессы спонтанной секреции ацетилхолина в нервно-мышечном синапсе крысы. Росс. Физиол. Ж. им. И.М. Сеченова. 2001; 87(4): 492-498.

Mukhtarov M.R., Urazaev A.Kh., Nikolsky E.E., Vyskočil F. Effect of nitric oxide and NO synthase inhibition on nonquantal acetylcholine release in the rat diaphragm. Eur. J. Neurosci. 2000; 12(3): 980-986.

Мухтаров М.Р., Уразаев А.Х., Никольский Е.Е., Выскочил Ф. Модуляция интенсивности неквантовой секреции медиатора в нервно-мышечном соединении крысы оксидом азота (NO). Росс. Физиол. Ж. им. И.М. Сеченова. 2000; 86(3): 335-342.

Mukhtarov M.R., Vyskočil F., Urazaev A.Kh., Nikolsky E.E. Non-quantal acetylcholine release is increased after nitric oxide synthase inhibition. Physiol. Res. 1999; 48(4): 315-317.

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