Personal Data
Name: Ilgam KHALILOV
Business Address:
Institut de Neurobiologie de la Méditerranée INMED UMR901 Parc scientifique de Luminy,
163 avenue de Luminy BP13 - 13273 Marseille cedex 09 - France
420008, Kazan Federal (Volga Region) University, room 024B, Kremlyovskaya St., 18, Kazan, Russia
Phone: +33 4 91 82 81 41; +7 (843) 233 78 24
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Date of Birth: 02.10.1960
Education and Academic Degrees
1979-1984 Higher Education, dept. of Physiology of Human and Animals, Kazan State University, USSR, CR1, PhD
Positions held
- Postdoctoral researcher, CR1 INSERM U901
- Postdoctoral researcher, Laboratory of Neurobiology, Kazan Federal University
Areas of Specializations
- Study of age-related changes in the action of the neurotransmitter gamma-aminobutyric acid, GABA;
- The role of GABA and chloride co-transporters in iktogeneze and epileptogenesis in the immature brain
Grants/Fellowships
- 2002 Fondation Française pour la Recherche sur l’Epilepsie (FFRE)
- 2009-2012 Contrat ANR (N décision: ANR-08-MNP-031) “Seizures beget seizures in infantile epilepsies: Crucial role of GABA and search of novel therapeutic strategies”
- 2011-2014 Contrat ANR (N décision : ANR 2010 BLAN 1405.04) “Epilepsie, Langage et Développement : réseaux moléculaires, physiopathologie et développement du cortex”
Honors and Awards
2001 EDF Research Prize
Publications
Depolarizing GABA and developmental epilepsies
Khazipov R., Valeeva G., Khalilov I.; CNS Neurosci. Ther., 2014, [Epub ahead of print] PDF
Intracellular Blockade of GABAa Receptors in the Rat Hippocampal Neurons
I. Khalilov, X. Leinekugel, M. Mukhtarov, R. Khazipov; Biochemistry (Moscow) Supplement Series A:
Membrane and Cell Biology, 2014, Vol. 8, No. 2, pp. 162–168.; 2014 PDF
Secondary epileptogenesis in the immature brain: a role of GABA
Khalilov I., Sitdikova G.F., Khazipov R.N., Zefirov A.L.; Zh. Nevrol. Psikhiatr. Im. S.S. Korsakova, 2014, V. 114, № 4, P. 41-51 PDF
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Tyzio R, Nardou R, Ferrari DC, Tsintsadze T, Shahrokhi A, Eftekhari S, Khalilov I, Tsintsadze V, Brouchoud C, Chazal G, Lemonnier E, Lozovaya N, Burnashev N, Ben-Ari Y. Oxytocin-mediated GABA inhibition during delivery attenuates autism pathogenesis in rodent offspring. Science. 2014 Feb 7;343(6171):675-9.
Salmi M, Bruneau N, Cillario J, Lozovaya N, Massacrier A, Buhler E, Cloarec R, Tsintsadze T, Watrin F, Tsintsadze V, Zimmer C, Villard C, Lafitte D, Cardoso C, Bao L, Lesca G, Rudolf G, Muscatelli F, Pauly V, Khalilov I, Durbec P, Ben-Ari Y, Burnashev N, Represa A, Szepetowski P. Tubacin prevents neuronal migration defects and epileptic activity caused by rat Srpx2 silencing in utero. Brain. 2013 Aug;136(Pt 8):2457-73.
Ben-Ari Y, Khalilov I, Kahle KT, Cherubini E. The GABA excitatory/inhibitory shift in brain maturation and neurological disorders. Neuroscientist. 2012 Oct;18(5):467-86. Epub 2012 Apr 30. Review.
Khalilov I, Chazal G, Chudotvorova I, Pellegrino C, Corby S, Ferrand N, Gubkina O, Nardou R, Tyzio R, Yamamoto S, Jentsch TJ, Hübner CA, Gaiarsa JL, Ben-Ari Y, Medina I. Enhanced Synaptic Activity and Epileptiform Events in the Embryonic KCC2 Deficient Hippocampus. Front Cell Neurosci. 2011 Nov 1;5:23.
Maksimov AV, Khasanov RN, Khalilov IG, Generalov MI, McManus S, Bulashova SA. [Emergency prosthetic repair of a ruptured abdominal aortic aneurysm]. Angiol Sosud Khir. 2011;17(3):65-8. Russian.
Nardou R, Yamamoto S, Bhar A, Burnashev N, Ben-Ari Y, Khalilov I. Phenobarbital but Not Diazepam Reduces AMPA/kainate Receptor Mediated Currents and Exerts Opposite Actions on Initial Seizures in the Neonatal Rat Hippocampus. Front Cell Neurosci. 2011 Jul 28;5:16.
Guihéneuf F, Leu S, Zarka A, Khozin-Goldberg I, Khalilov I, Boussiba S. Cloning and molecular characterization of a novel acyl-CoA:diacylglycerol acyltransferase 1-like gene (PtDGAT1) from the diatom Phaeodactylum tricornutum. FEBS J. 2011 Oct;278(19):3651-66.
Nardou R, Yamamoto S, Chazal G, Bhar A, Ferrand N, Dulac O, Ben-Ari Y, Khalilov I. Neuronal chloride accumulation and excitatory GABA underlie aggravation of neonatal epileptiform activities by phenobarbital. Brain. 2011 Apr;134(Pt 4):987-1002.
Tyzio R, Allene C, Nardou R, Picardo MA, Yamamoto S, Sivakumaran S, Caiati MD, Rheims S, Minlebaev M, Milh M, Ferré P, Khazipov R, Romette JL, Lorquin J, Cossart R, Khalilov I, Nehlig A, Cherubini E, Ben-Ari Y. Depolarizing actions of GABA in immature neurons depend neither on ketone bodies nor on pyruvate. J Neurosci. 2011 Jan 5;31(1):34-45.
Tyzio R, Khalilov I, Represa A, Crepel V, Zilberter Y, Rheims S, Aniksztejn L, Cossart R, Nardou R, Mukhtarov M, Minlebaev M, Epsztein J, Milh M, Becq H, Jorquera I, Bulteau C, Fohlen M, Oliver V, Dulac O, Dorfmüller G, Delalande O, Ben-Ari Y, Khazipov R. Inhibitory actions of the gamma-aminobutyric acid in pediatric Sturge-Weber syndrome. Ann Neurol. 2009 Aug;66(2):209-18.
Nardou R, Ben-Ari Y, Khalilov I. Bumetanide, an NKCC1 antagonist, does not prevent formation of epileptogenic focus but blocks epileptic focus seizures in immature rat hippocampus. J Neurophysiol. 2009 Jun;101(6):2878-88.
Tyzio R, Cossart R, Khalilov I, Minlebaev M, Hübner CA, Represa A, Ben-Ari Y, Khazipov R. Maternal oxytocin triggers a transient inhibitory switch in GABA signaling in the fetal brain during delivery. Science. 2006 Dec 15;314(5806):1788-92.
Maksimov AV, Mamaev VE, Khalilov IG, Mardeeva GR. Reconstruction of the aortofemoral segment using a minilaparotomy access. Experience with 100 operations. Angiol Sosud Khir. 2006;12(2):106-14. English, Russian.
Le Van Quyen M, Khalilov I, Ben-Ari Y. The dark side of high-frequency oscillations in the developing brain. Trends Neurosci. 2006 Jul;29(7):419-27.
Khalilov I, Le Van Quyen M, Gozlan H, Ben-Ari Y. Epileptogenic actions of GABA and fast oscillations in the developing hippocampus. Neuron. 2005 Dec 8;48(5):787-96.
Ben-Ari Y, Khalilov I, Represa A, Gozlan H. Interneurons set the tune of developing networks. Trends Neurosci. 2004 Jul;27(7):422-7. Review.
Khazipov R, Khalilov I, Tyzio R, Morozova E, Ben-Ari Y, Holmes GL. Developmental changes in GABAergic actions and seizure susceptibility in the rat hippocampus. Eur J Neurosci. 2004 Feb;19(3):590-600.
Khalilov I, Holmes GL, Ben-Ari Y. In vitro formation of a secondary epileptogenic mirror focus by interhippocampal propagation of seizures. Nat Neurosci. 2003 Oct;6(10):1079-85.
Demarque M, Represa A, Becq H, Khalilov I, Ben-Ari Y, Aniksztejn L. Paracrine intercellular communication by a Ca2+- and SNARE-independent release of GABA and glutamate prior to synapse formation. Neuron. 2002 Dec 19;36(6):1051-61.
Hennou S, Khalilov I, Diabira D, Ben-Ari Y, Gozlan H. Early sequential formation of functional GABA(A) and glutamatergic synapses on CA1 interneurons of the rat foetal hippocampus. Eur J Neurosci. 2002 Jul;16(2):197-208.
Khalilov I, Hirsch J, Cossart R, Ben-Ari Y. Paradoxical anti-epileptic effects of a GluR5 agonist of kainate receptors. J Neurophysiol. 2002 Jul;88(1):523-7.
Morozov Y, Khalilov I, Ben-Ari Y, Represa A. Correlative fluorescence and electron microscopy of biocytin-filled neurons with a preservation of the postsynaptic ultrastructure. J Neurosci Methods. 2002 May 30;117(1):81-5.
Khuzhamshukurov NA, Iusupov TIu, Khalilov IM, Guzalova AG, Muradov MM, Davranov KD. [Insecticidal activity of Bacillus thuringiensis cells]. Prikl Biokhim Mikrobiol. 2001 Nov-Dec;37(6):698-701. Russian.
Belov IuV, Stepanenko AB, Gens AP, Khalilov IG. [Assessment of the results of surgical treatment of multiple lesions of lower limb arteries]. Khirurgiia (Mosk). 2001;(10):33-6. Russian.
Khazipov R, Esclapez M, Caillard O, Bernard C, Khalilov I, Tyzio R, Hirsch J, Dzhala V, Berger B, Ben-Ari Y. Early development of neuronal activity in the primate hippocampus in utero. J Neurosci. 2001 Dec 15;21(24):9770-81.
Dzhala V, Khalilov I, Ben-Ari Y, Khazipov R. Neuronal mechanisms of the anoxia-induced network oscillations in the rat hippocampus in vitro. J Physiol. 2001 Oct 15;536(Pt 2):521-31.
Gaïarsa JL, Khalilov I, Gozlan H, Ben-Ari Y. Morphology of CA3 non-pyramidal cells in the developing rat hippocampus. Brain Res Dev Brain Res. 2001 Apr 30;127(2):157-64.
Khalilov I, Dzhala V, Ben-Ari Y, Khazipov R. Dual role of GABA in the neonatal rat hippocampus. Dev Neurosci. 1999 Nov;21(3-5):310-9.
Khalilov I, Dzhala V, Medina I, Leinekugel X, Melyan Z, Lamsa K, Khazipov R, Ben-Ari Y. Maturation of kainate-induced epileptiform activities in interconnected intact neonatal limbic structures in vitro. Eur J Neurosci. 1999 Oct;11(10):3468-80.
Leinekugel X, Khalilov I, McLean H, Caillard O, Gaiarsa JL, Ben-Ari Y, Khazipov R. GABA is the principal fast-acting excitatory transmitter in the neonatal brain. Adv Neurol. 1999;79:189-201. Review.
Khazipov R, Desfreres L, Khalilov I, Ben-Ari Y. Three-independent-compartment chamber to study in vitro commissural synapses. J Neurophysiol. 1999 Feb;81(2):921-4.
Leinekugel X, Khalilov I, Ben-Ari Y, Khazipov R. Giant depolarizing potentials: the septal pole of the hippocampus paces the activity of the developing intact septohippocampal complex in vitro. J Neurosci. 1998 Aug 15;18(16):6349-57.
Khalilov I, Esclapez M, Medina I, Aggoun D, Lamsa K, Leinekugel X, Khazipov R, Ben-Ari Y. A novel in vitro preparation: the intact hippocampal formation. Neuron. 1997 Oct;19(4):743-9.
Leinekugel X, Medina I, Khalilov I, Ben-Ari Y, Khazipov R. Ca2+ oscillations mediated by the synergistic excitatory actions of GABA(A) and NMDA receptors in the neonatal hippocampus. Neuron. 1997 Feb;18(2):243-55.
Khazipov R, Leinekugel X, Khalilov I, Gaiarsa JL, Ben-Ari Y. Synchronization of GABAergic interneuronal network in CA3 subfield of neonatal rat hippocampal slices. J Physiol. 1997 Feb 1;498 ( Pt 3):763-72.
Khalilov I, Khazipov R, Esclapez M, Ben-Ari Y. Bicuculline induces ictal seizures in the intact hippocampus recorded in vitro. Eur J Pharmacol. 1997 Jan 29;319(2-3):R5-6.
Sitdikova GF, Khalilov IA, Zefirov AL. [The effect of phenol on the ion currents of the frog motor nerve ending]. Fiziol Zh Im I M Sechenova. 1996 Jul;82(7):78-84.
Bubnov IuI, Arabidze GG, Maksimova NV, Khalilov I, Kutsenko AI, Koshechkin VA. [Familial and nonfamilial forms of arterial hypertension]. Ter Arkh. 1993;65(12):16-9. Russian.
Zefirov AL, Shakir'ianova DM, Khalilov IA, Nikol'skiĭ EE. [The effect of exogenous acetylcholine on the ion currents of the motor nerve ending in the frog and the mouse]. Biull Eksp Biol Med. 1992 Jul;114(8):124-6. Russian.
Zefirov AL, Khalilov IA. [The generation and spread of excitation in the motor nerve ending of the frog]. Biull Eksp Biol Med. 1990 Mar;109(3):219-22. Russian.
Dobretsov MG, Zefirov AL, Kurtasanov RS, Khalilov IA, Vinogradova IM. [The formation of nerve endings in the phasic muscles of the frog]. Neirofiziologiia. 1990;22(1):99-107. Russian.
Petrov VV, Arabidze GG, Levitskiĭ DO, Eliseev AO, Grishenkov EA, Kaĭkov MI, Khalilov IE. [Na-Li countertransport and the diagnosis of hypertension and combined hypertension and renal artery stenosis]. Ter Arkh. 1990;62(6):124-9. Russian.
Khamidov DKh, Makhkamov EU, Khalilov I, Mamedov TG, Inogamov ZN. [Morphological characteristics of the muscles of the soft palate in children with congenital cleft lip and palate]. Stomatologiia (Mosk). 1988 May-Jun;67(3):62-5. Russian.
Makhkamov EU, Murtazaev SM, Komarin AS, Azizov ShS, Khalilov IKh. [Intestinal absorption in children with congenital cleft upper lip and palate]. Stomatologiia (Mosk). 1987 Jul-Aug;66(4):58-60. Russian.
Dobretsov MG, Drabkina TM, Zefirov AL, Matiushkin DP, Khalilov IA. [Presence of a specific (not associated with the modification of currents in nerve endings) positive effect of K+ on the release of a mediator]. Dokl Akad Nauk SSSR. 1987;297(4):1010-3. Russian.
Zefirov AL, Khalilov IA, Khamitov KhS. [Calcium and calcium-activated potassium currents of motor nerve endings in the frog]. Neirofiziologiia. 1987;19(4):467-73. Russian.
Zefirov AL, Kashapova LA, Moshkov DA, Bezgina EN, Khalilov IA. [Electrophysiological and ultrastructural study of the topography of active zones in the motor nerve terminal of the frog]. Dokl Akad Nauk SSSR. 1986;290(5):1277-80. Russian.
Zefirov AL, Khalilov IA. [Characteristics of electrical activity in different sections of nerve endings in the frog]. Biull Eksp Biol Med. 1985 Jan;99(1):7-10. Russian.
Zefirov AL, Khalilov IA. [Ion currents of a nerve ending in the sartorial muscle of the frog]. Neirofiziologiia. 1985;17(6):770-9. Russian.
Zefirov AL, Khalilov IA, Khamitov KhS. [Calcium current of nerve ending in the frog]. Dokl Akad Nauk SSSR. 1985;282(3):744-6. Russian.
Khalilov IM, Avanesov AA, Ganiev KD. [Congenital alopecia and hypotrichosis]. Vestn Dermatol Venerol. 1977 Aug;(8):66-8. Russian.
Khalilov IKh. [From the history of the control of syphilis in Dagestan in the pre-revolution period]. Vestn Dermatol Venerol. 1973 Aug;47(8):54-7. Russian.
Khalilov IKh. [Role of chronic trichophytosis in adults in the epidemiology of mycotic diseases in Dagestan]. Vestn Dermatol Venerol. 1971 Oct;45(10):30-5. Russian.
Khalilov IM, Vasil'eva NN, Mitin KS. [Results of histological and histochemical study of favus in patients treated with radiation, epilon, and griseofulvin]. Vestn Dermatol Venerol. 1970 Sep;44(9):48-52. Russian.
Khalilov IM, Avanesov AA. [Remote results of griseofulvin therapy of trichomycoses]. Vestn Dermatol Venerol. 1968 Aug;42(8):80-2. Russian.
Khalilov IM, Frolova TG, Dzhamalova VZ, Alieva NK. [Treatment of trichomycoses with griseofulvin]. Vestn Dermatol Venerol. 1967 Jul;41(7):81-4. Russian.
Khalilov IM, Frolova TG. [Use of cold in treatment of deep trichophytosis and parasitic sycosis]. Vestn Dermatol Venerol. 1967 Feb;41(2):79-80. Russian.
KHALILOV IM. [BEH CET'S DISEASE]. Vestn Dermatol Venerol. 1963 Oct;37:72-5. Russian.
